Reza Alizadeh-Navaei; Majid Saeedi; Reza Valadan; Fatemeh Roozbeh; Omolbanin Amjadi; Ehsan Zaboli; Mahmood Moosazadeh; Hossein Ranjbaran; Zinab Qazizadeh; Ali Akbari-Malekshah; Touraj Assadi; Versa Omrani-Nava; Akbar Hedayatizadeh-Omran
Volume 22, Issue 7 , 2020
Abstract
Background: Coronavirus is a single-stranded RNA virus, causing an epidemic of pneumonia and acute respiratory distress syn- drome (ARDS) worldwide in late 2019.
Objectives: In addition to the clinical symptoms, laboratory diagnosis can greatly help diagnose the diseases; therefore, this study aimed ...
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Background: Coronavirus is a single-stranded RNA virus, causing an epidemic of pneumonia and acute respiratory distress syn- drome (ARDS) worldwide in late 2019.
Objectives: In addition to the clinical symptoms, laboratory diagnosis can greatly help diagnose the diseases; therefore, this study aimed to analyze laboratory parameters in patients with COVID-19.
Methods: In this cross-sectional study, the laboratory data of 2563 patients with COVID-19 admitted to hospitals affiliated with Mazandaran University of Medical Sciences were extracted from hospital information systems (HIS). The data were recorded on Excel and analyzed through t-test, chi-squared, and Fishers exact tests in SPSS 19 at the significance level of P < 0.05.
Results: Out of 2563 patients with a mean age of 55.1 ± 16.7 years, 1409 (55%) were male, and 1154 (45%) were female with a mean age of 55.7 ± 16.8, and 54.3 ± 16.6 years, respectively. As the most frequent clinical findings, ESR, CRP, and LDH were increased by 83.5%, 71%, and 69.3% of the patients, respectively. Other research findings included lymphopenia, disturbed INR, abnormal SGOT, abnormal alkaline phosphatase (ALP), and increased lactate dehydrogenase (LDH), which were significantly higher in men than in women and was different between age groups.
Conclusions: Conducting simple, convenient, and inexpensive laboratory tests can be helpful in the diagnosis of COVID-19.
Tahoora Mousavi; Mahmood Moosazadeh; Mahdi Afshari; Lotfollah Davoodi; Mohammadreza Haghshenas
Volume 19, Issue 4 , April 2017, , Pages 1-10
Abstract
Context: Cervical and genital infections are responsible for the more common sexually transmitted cancers among women aged 14 - 55 years. There are more than 100 HPV types which cause 60% - 70% (high risk types: 16, 18) and 90% (low risk types: 6, 11) cervical cancers. This study aimed to evaluate the ...
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Context: Cervical and genital infections are responsible for the more common sexually transmitted cancers among women aged 14 - 55 years. There are more than 100 HPV types which cause 60% - 70% (high risk types: 16, 18) and 90% (low risk types: 6, 11) cervical cancers. This study aimed to evaluate the efficacy of L1 protein vaccines against cervical and vaginal cancer.Evidence Acquisition: Different databases (including Scopus, Google scholar, PubMed, Cochrane, and Science Direct) weresearched using relevant keywords such as Gardasil, Cervarix, and cervical cancer. After restricting the search strategy and excluding duplicates, the remained articles were screened by investigating their titles, abstracts, and full texts. Cochrane Q-test and I-squared index were used to detect the heterogeneity among the results, and fixed effect model was applied to estimate the pooled risk ratio.Results: By combining the results of 10 primary articles, the efficacy of monovalent (HPV16), bivalent (HPV 16, 18), and quadrivalent (HPV16,11,6,8) vaccines was estimated between 86% and 100%.Conclusions: The results of this meta-analysis showed that Gardasil and Cervarix vaccines are highly effective against cervical cancer. According to the point that approximately 50% of cervical cancers and human carcinogenicity are related to HPV-16 infection, the bivalent HPV vaccine might have protective effects against HPV-16 CIN2-3 lesion and cervical cancer.
